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Research-onlyVendors pendingFacts verified · 2026-05-25

Epitalon

Also known as Epitalon (Epithalon), epithalon, epithalone, aedg · Wikipedia

Epitalon (Epithalon, AEDG) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by the Khavinson group at the St. Petersburg Institute of Bioregulation and Gerontology as a peptide-fragment mimetic of pineal-derived Epithalamin. It is positioned in the longevity/anti-aging space on the basis of Russian studies reporting induction of telomerase activity, telomere lengthening in cultured human somatic cells, restoration of melatonin rhythms, and modest lifespan extension in rodents. It has no Western regulatory approval, no published human pharmacokinetics, and minimal independent replication. Also known as Epithalon, Epithalone, and AEDG.

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Mechanism of action

Epitalon (Ala-Glu-Asp-Gly) is hypothesized to act via direct binding to gene promoters and chromatin, inducing expression of telomerase reverse transcriptase (TERT) with consequent telomere elongation in cultured human fibroblasts and other somatic cells (https://pmc.ncbi.

Epitalon (Ala-Glu-Asp-Gly) is hypothesized to act via direct binding to gene promoters and chromatin, inducing expression of telomerase reverse transcriptase (TERT) with consequent telomere elongation in cultured human fibroblasts and other somatic cells (https://pmc.ncbi.nlm.nih.gov/articles/PMC12411320/), and via restoration of pineal melatonin secretion and circadian gene expression. Recent in vitro work also reports upregulation of neurogenic genes and protein synthesis (https://pubmed.ncbi.nlm.nih.gov/32019204/) and antioxidant/wound-healing effects in retinal models. No defined receptor target has been identified, plasma pharmacokinetics are essentially unpublished, and the mechanistic literature is dominated by a single research group (https://pmc.ncbi.nlm.nih.gov/articles/PMC11943447/), so mechanism remains hypothesis-grade rather than established.

Pharmacokinetic properties

Half-life

Unknown — published PK data essentially nonexistent; presumed minutes for the free tetrapeptide

Routes

subcutaneous · intramuscular · intranasal

Bioavailability

Oral bioavailability negligible due to peptidase degradation. Most Russian studies used parenteral routes; intranasal use is popular in the self-experimentation community but unvalidated.

Amino-acid sequence

Ala-Glu-Asp-Gly

Use & research dosing

Healthy AgingCircadian Support

There is no clinically validated human dose. In Khavinson-group publications, parenteral (IM/SC) doses of 5-10 mg/day for 10-20 day cycles, repeated 1-2 times per year, are most commonly described. Self-experimentation protocols often use 5-10 mg/day SC for 10-20 days as a single annual or semi-annual cycle. Intranasal administration is popular in the user community but is not validated by published PK data. Research framing only.

Research-use framing only. SavePeptides sells nothing for human consumption. Doses above reflect reported research / self-experimentation ranges, not clinical recommendations.

Editorial perspective

The telomerase-activation, telomere-lengthening, and lifespan-extension claims rest predominantly on publications from the Khavinson group at the St. Petersburg Institute of Bioregulation and Gerontology. Independent Western replication is essentially absent and a 2025 correction was issued on one of the recent telomere papers. Treat all anti-aging efficacy claims as low-evidence and exploratory. Frequently stacked with other Khavinson 'bioregulator' peptides (Thymalin, Thymogen, Vilon) and with NAD precursors, but no controlled human stack data exist.

— SavePeptides editorial desk · last updated 2026-05-25

Cautions & contraindications

Before researching this compound, note:

  • Telomerase-activation and TERT-induction claims raise theoretical concern in patients with active or prior malignancy
  • Not FDA- or EMA-approved; sold as a research chemical or 'bioregulator/dietary supplement' in Russia only
  • Almost all efficacy data come from a single research group (Khavinson, St. Petersburg) with limited Western replication
  • Unknown long-term safety in humans; no controlled multi-year studies
  • Sterility, purity, and identity of research-grade material are highly variable between vendors
  • Pregnancy and lactation - avoid (no safety data)
  • Pediatric use - avoid (no data)
  • Potential confounding interaction with melatonin or circadian-modifying drugs (theoretical)

Research foundation

The papers behind the page.

  1. [01]https://pmc.ncbi.nlm.nih.gov/articles/PMC11943447/
  2. [02]https://pmc.ncbi.nlm.nih.gov/articles/PMC12411320/
  3. [03]https://pubmed.ncbi.nlm.nih.gov/32019204/
  4. [04]https://pmc.ncbi.nlm.nih.gov/articles/PMC12356729/

Facts verified

2026-05-25

Confidence

low

What this means

  • evidence base is primarily Russian-language / Khavinson institute
  • no published human pharmacokinetics
  • telomerase claims not independently replicated

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Epitalon · SavePeptides