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Research-onlyVendors pendingFacts verified · 2026-05-25

Cartalax

Also known as aed, t‑31, alanyl‑glutamyl‑aspartate · Wikipedia

Cartalax is a synthetic tripeptide bioregulator with the sequence Ala-Glu-Asp (AED), developed by the Khavinson school at the St. Petersburg Institute of Bioregulation and Gerontology and marketed as a cartilage-and-connective-tissue 'bioregulator.' It belongs to the same family of ultra-short peptides as Epitalon (AEDG), Pinealon (EDR), and Vilon (KE), and is hypothesized to enter cells and bind directly to gene promoter regions in chondrocytes and fibroblasts to modulate transcription of collagen type II, aggrecan, and other extracellular-matrix components. Almost all published evidence is in Russian-language preclinical literature and cell culture; rigorous Western-style human trials are absent.

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Mechanism of action

Cartalax (Ala-Glu-Asp, AED) is a Khavinson short-peptide bioregulator. The Khavinson hypothesis is that ultra-short peptides cross plasma and nuclear membranes and bind directly to specific promoter sequences in chondrocytes and fibroblasts, modulating transcription of cartilage-matrix genes including type II collagen and aggrecan.

Cartalax (Ala-Glu-Asp, AED) is a Khavinson short-peptide bioregulator. The Khavinson hypothesis is that ultra-short peptides cross plasma and nuclear membranes and bind directly to specific promoter sequences in chondrocytes and fibroblasts, modulating transcription of cartilage-matrix genes including type II collagen and aggrecan. Reported effects in Russian preclinical literature include normalization of chondrocyte function, anti-inflammatory action in joint tissues, and support of cartilage matrix integrity in aging-model animals (reviewed in PMC10179481, PMC6376556). The proposed gene-promoter-binding mechanism has not been independently replicated in Western laboratories, and rigorous receptor pharmacology, pharmacokinetics, and oral bioavailability data in humans are not published.

Pharmacokinetic properties

Half-life

unknown - short peptides of this class are assumed to be rapidly cleared from plasma but to act via tissue-localized intracellular binding

Routes

subcutaneous · intramuscular · oral

Bioavailability

Khavinson short peptides are claimed to retain activity orally because of small size, but rigorous human bioavailability data are absent. Russian capsule formulations are sold for oral use.

Amino-acid sequence

Ala-Glu-Asp (AED)

Use & research dosing

Research framing only. Russian product monographs cite injectable courses of 5-10 mg subcutaneously or intramuscularly daily for 10-20 days, repeated every 3-6 months. Oral capsule formulations are sold at roughly 200-400 mcg per capsule taken once or twice daily for 1-3 month courses. None of these regimens have been validated in controlled human trials; they reflect manufacturer monograph recommendations rather than dose-finding studies. Oral bioavailability of such short peptides in humans is uncharacterized. Buyers should treat all circulating dose ranges as anecdotal.

Research-use framing only. SavePeptides sells nothing for human consumption. Doses above reflect reported research / self-experimentation ranges, not clinical recommendations.

Editorial perspective

Cartalax sits in the Khavinson 'bioregulator' family alongside Epitalon, Pinealon, Vilon, and the organ-targeted peptides (Cardiogen, Thymalin, Prostamax). The mechanistic claim - direct binding of ultra-short peptides to gene promoters - remains contested outside the St. Petersburg group, and Western preclinical and clinical replication is limited. Buyers should regard joint and cartilage support claims as preliminary. The compound is sold for both injectable and oral courses despite the absence of human pharmacokinetic data for either route.

— SavePeptides editorial desk · last updated 2026-05-25

Cautions & contraindications

Before researching this compound, note:

  • No FDA or EMA approval; classified as research chemical or dietary supplement outside Russia
  • Evidence base is largely Russian-language preclinical literature; no Western controlled human trials
  • Pregnancy and breastfeeding - no human safety data
  • Pediatric use not studied
  • Active malignancy - all bioregulator peptides should be avoided pending long-term oncology safety data given proposed transcription-modulating mechanism
  • Vendor purity and identity of the AED tripeptide are not independently verified
  • Unknown drug-drug interactions; no pharmacokinetic profiling
  • Allergic or injection-site reactions possible with injectable formulations
  • Long-term safety unknown; chronic use of transcription-modulating peptides lacks human follow-up data
  • Therapeutic claims for joint and cartilage support are not supported by rigorous controlled trials

Facts verified

2026-05-25

Confidence

low

What this means

  • russian-only-evidence
  • khavinson-bioregulator
  • no-western-human-trials

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