Also known as delta sleep-inducing peptide, emideltide · Wikipedia
DSIP (Delta Sleep-Inducing Peptide, emideltide) is a nine-amino-acid peptide originally isolated in the 1970s from rabbit cerebral venous blood during sleep induction experiments by Schoenenberger and Monnier. It is occasionally explored in research-only protocols for sleep architecture, stress response, and pain modulation, but its molecular target has never been identified and modern sleep medicine does not regard it as a validated hypnotic. Human data are limited to small Russian and European studies from the 1980s with weak methodology. Marketed only as a research chemical, with no regulatory approval anywhere. Also known as: delta sleep-inducing peptide, emideltide.
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Browse all vendorsMechanism of action
DSIP is a nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) whose molecular target remains unidentified despite five decades of investigation. No high-affinity DSIP receptor has been cloned or pharmacologically characterized (https://pubmed.
Pharmacokinetic properties
Half-life
~15-30 minutes plasma
Routes
subcutaneous · intravenous · intranasal
Bioavailability
Oral bioavailability is poor (peptide). IV has higher bioavailability than SC. Some sources claim DSIP crosses the BBB, but evidence is mixed.
Amino-acid sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Use & research dosing
No FDA-approved or guideline-supported dose exists. In historical clinical investigations DSIP was given intravenously at 25-50 nmol/kg. In contemporary self-experimentation literature it is commonly reported at 100-300 mcg subcutaneously administered 30-60 minutes before sleep, occasionally up to 500 mcg, in short courses of 1-4 weeks rather than chronic use. Framing is research only; no validated dose-response or efficacy data support any specific regimen.
Research-use framing only. SavePeptides sells nothing for human consumption. Doses above reflect reported research / self-experimentation ranges, not clinical recommendations.
Despite the evocative name, modern sleep medicine does not consider DSIP a validated sleep aid. The receptor remains uncloned and human RCT evidence is essentially absent. The most-cited reviews call it 'a still unresolved riddle.' Marketing claims of reliable sleep induction, anxiolysis, or longevity effects far exceed what the published evidence supports, and most positive human data come from small, old, methodologically weak Soviet-era studies. Confidence in the evidence base is low.
— SavePeptides editorial desk · last updated 2026-05-25
Cautions & contraindications
Research foundation
Facts verified
2026-05-25
Confidence
low
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