Also known as pegylated igf-1ec e-peptide, peg-mgf · Wikipedia
PEG-MGF is the pegylated form of Mechano Growth Factor, the C-terminal E-peptide of the IGF-1Ec splice variant produced in mechanically loaded skeletal muscle. PEGylation extends the very short native half-life and allows systemic (subcutaneous) dosing, in contrast to unpegylated MGF which is typically used by local intramuscular injection post-exercise. It is marketed in the research-chemical channel for muscle repair and hypertrophy support, but no published human clinical trials exist for PEG-MGF specifically, and the underlying MGF biology itself remains debated, with some studies failing to replicate the satellite-cell effects.
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Browse all vendorsMechanism of action
PEG-MGF is the polyethylene-glycol-conjugated form of Mechano Growth Factor (MGF), the C-terminal E-domain peptide of the IGF-1Ec splice variant. The E-peptide is hypothesized to act independently of the IGF-1 receptor on quiescent muscle satellite cells, promoting their proliferation and delaying differentiation, thereby expanding the local myogenic stem-cell pool available for repair (Mills et al.
Pharmacokinetic properties
Half-life
Several hours to ~48-72 hours (estimates vary; uncharacterized in peer-reviewed human PK studies)
Routes
subcutaneous · intramuscular
Bioavailability
PEG conjugation extends native MGF's ~5-7 minute plasma half-life dramatically. Systemic dosing 1-2x weekly typical; native (unpegylated) MGF requires local intramuscular dosing post-workout.
Amino-acid sequence
(PEGylated MGF E-peptide; see IGF-1Ec literature)
Use & research dosing
No FDA-approved indication and no published human clinical trials with PEG-MGF specifically. Self-experimentation protocols circulating in the research-chemical channel commonly report 200-500 mcg subcutaneously or intramuscularly 1-3 times per week, sometimes timed post-workout. By contrast, native (unpegylated) MGF is typically used by local intramuscular injection immediately post-workout because of its very short plasma half-life of approximately 5-7 minutes. Research framing only.
Research-use framing only. SavePeptides sells nothing for human consumption. Doses above reflect reported research / self-experimentation ranges, not clinical recommendations.
Mechanistically distinct from systemic IGF-1: claimed to act on the local muscle stem-cell pool rather than the IGF-1 receptor. PEGylation is essential for systemic dosing because native MGF is cleared in minutes. The underlying biology is contested - some groups reproduce satellite-cell proliferation effects, others do not, and the receptor target has not been definitively identified. No human clinical trial data with PEG-MGF exist.
— SavePeptides editorial desk · last updated 2026-05-25
Cautions & contraindications
Research foundation
Facts verified
2026-05-25
Confidence
low
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